Vhl Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comVhl Polyclonal Antibody for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Vhl(Gene name) > Mouse

Vhl (Gene name),

Von Hippel-Lindau disease tumor suppressor (Protein name ), VHL_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Vhl(Vhlh);

Protein name:

Von Hippel-Lindau disease tumor suppressor;

Alternative:

pVHL;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Part of a complex with Elongin BC complex and hydroxylated HIF1A. Interacts with CUL2. Part of multisubunit CBC(VHL) E3 ubiquitin ligase complexes with Elongin BC complex, CUL2 or CUL5 and RBX1. Interacts with HIF1AN. Part of a complex with HIF1A, HIF1AN and HDAC1 or HDAC2 or HDAC3. The C-terminus interacts with VBP1. Interacts with RNF139 and USP33. Interacts with PHF17.

Function:

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Nucleus

Protein Attributes:

Sequence length:

181

Sequence:

50:

100:

150:

181:

YEDLEDYPSV | RKDIQRLSQE | HLESQHLEEE | P

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Mm.29407

Pfam:

PF01847

STRING:

10090.ENSMUSP00000039418

String:

P40338

KEGG:

mmu:22346

SMR:

P40338

Uniprot:

P40338

FOR

ELISA Kit for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

E1894h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

E1894r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

E1894m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

E1894d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

U1894d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

U1894h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

U1894m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

U1894r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

P1894Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

P1894Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Von Hippel-Lindau disease tumor suppressor

Cat.:

P1894Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Von Hippel-Lindau disease tumor suppressor

Protein for Mouse Von Hippel-Lindau disease tumor suppressor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of the Von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis."
Kessler P.M. , Vasavada S.P. , Rackley R.R. , Stackhouse T. , Duh F.-M. , Latif F. , Lerman M.I. , Zbar B. , Williams B.R.
Mol. Med.1:457-466(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE
strain: ICR.
tissue: Brain.
2.

"Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: implications for the potential organization of the human von Hippel-Lindau disease gene."
Gao J. , Naglich J.G. , Laidlaw J. , Whaley J.M. , Seizinger B.R. , Kley N.
Cancer Res.55:743-747(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Human DNA blueprints protecting the VHL promoter and CpG island from methylation are functional in the mouse."
Kuzmin I. , Geil L. , Schmidt L. , Duh F.-M. , Feigenbaum L. , Nickerson M.L. , Ma W. , Stanbridge E.J. , Zbar B. , Lerman M.I.
Submitted (2002-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE
strain: 129/SvJ.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.

Product Feedback Wall

* Email:
*Comments: